The Trinity Biomedical Sciences Institute (TBSI) is an environment where innovative and interdisciplinary approaches are leading to scientific discoveries of biomedical importance, ultimately giving rise to better patient care. The mechanistic basis for a whole range of diseases is under investigation, including infectious and inflammatory diseases such as arthritis and Type 2 diabetes, neurological diseases such as motor neuron disease and multiple sclerosis, and different forms of cancer. Our focus is on outstanding discovery, since there remains a major unmet medical need for the treatment of these diseases and our understanding of the molecular basis of many diseases remains limited.